Alzheimer’s Evolves Way Before The Symptoms Emerge, Study Confirms

In a recent research study at  Indiana University, according to Business Standard Reports it has been observed that buildup of certain types of plaques in the brain tissue could signify the development of Alzheimer’s disease way earlier than any symptoms emerge, which can lead to memory loss and diminished mental function.

Researchers studying the progressive Alzheimer’s disease discovered that it could already be “at work” in the brain years before actual symptoms start showing.
Alzheimer’s accounts for 60 to 70% cases of Dementia. People suffering from this chronic neurodegenerative disease have an average life expectancy of three to nine years, following diagnosis.
According to researchers the most recognized genetic variant that is linked to Alzheimer’s disease may be multiplying accumulations of plaque in the brain way earlier than any of the symptoms of the disease are gauged through tests.
This study focalizes on “significant memory concerns” in which older adults who were having trouble recalling memories from past (recent months and years) Despite this concern, most participants tested within normal ranges for cognition and memory.

Authors Shannon L. Risacher and Andrew J. Saykin analyzed genetic data from almost 600 patients, searching for the APOE e4 gene and its variants. They found that among the group of patients with “significant memory concerns,” there was evidence of Alzheimer’s-like pathologies in individuals who carried the gene and its variants.

The authors conducting this study, Shannon L. Risacher, Ph.D., and Andrew J. Saykin, Psy.D analyzed data from approximately 600 ADNI patients looking for the APOE e4 gene and its variants. They concluded that among all the patients having ‘significant memory concerns’ they found pathologies similar to Alzheimer’s, who carried those genes and its variants.
Scientists confirmed they have found pathologies similar to Alzheimer’s through various bio markers among the APOE e4 carriers in the significant memory group”

The team now had evidence of bio markers which included raised levels of amyloid plaque, the mass of protein fragments often spotted in the brain tissue of patients suffering from Alzheimers.

Scientists also concluded that a deteriorated level of protein precursor of plaques in the (CSF) cerebrospinal fluid, demonstrates that the protein was being utilized in the brain as part of the plaque formation process. Also, an increase in level of tau, which is another protein associated with Alzheimer’s in the cerebrospinal fluid.

However, the survey did not obtain any proof of atrophy of brain structures or condensed levels of glucose metabolism that are linked to late phases of Alzheimer’s development

Dr. Risacher feels that there is ample room for further research amongst patients who are at a high risk of Alzheimer’s disease.

This survey has been published in the journal: Alzheimer`s and Dementia.



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