“Based on this nationwide study on the association between PD (Parkinson disease) and cancer risk, we conclude that PD is a risk factor for most cancer in Taiwan,” said Pan-Chyr Yang of the National Taiwan University College of Medicine, Taipei. “The striking differences between our study and the previous studies in Western cohorts suggest the importance of ethnicity and environmental exposures in disease pathogenesis,” Yang concluded. The study, which appeared online in the journal JAMA Oncology, was done with a final study group of 62,023 patients newly diagnosed with PD from 2004 through 2010 and 124,046 control participants without PD. The study group was built by the researchers using Taiwan National Health Insurance Research Database.
A diagnosis of Parkinson’s disease was not associated with increased risk of breast, ovarian or thyroid cancers.
In the study, only breast, ovarian and thyroid cancers were found not to be associated with PD.
But, PD appeared associated (as measured by increased hazard ratios) with 16 other cancers including malignant brain tumours, gastrointestinal tracts cancers, lung cancers, some hormone-related cancers, urinary tract cancers, lymphoma/leukemia, melanoma and other skin cancers.