Migraine sufferers usually get a headache which affects half of the head and can last up to 72 hours. Nausea, vomiting, sensitivity to light, sound and smell are all the ailments affecting the patients suffering from Migraine. Any sort of physical activity worsens the pain. Believed to be a Neurovascular disorder, extra mechanisms of Migraine are yet unknown.
Competing research firms have submitted parallel studies, through which a new class of drugs is being developed that could miraculously prevent chronic migraines. Scientists believe that the drugs could interrupt the process of events that lead up to a migraine before it even starts.
This is all very exciting for people who have not had good treatment; these drugs could be a form of prevention without a lot of side effects states Dr. Thomas Ward from Dartmouth University Geisel School of Medicine. Furthermore he hopes that the drugs will be clean, reduce the number of headaches in people and won’t carry a lot of side effects.
CGRP (calcitonin-gene-related peptide) is a specific biochemical which is being targeted through his new class of drugs. Clinical trials have proved that these drugs can be an effective measure in preventing migraine in a significant amount of the population of headache sufferers.
The American Headache Society chair of the scientific program and chief of the University of California, San Francisco Headache Center, Dr. Peter, Goadsby states that researchers have identified the important role CGRP plays in the development of migraine headaches, since 20 years.
It has been known since 20 years that the body requires CGRP in order to control the opening of blood vessels. Ward believes that CGRP plays a very vital role in pain signal transmission.
“The last step in the pathway we think to setting off headache is this substance called CGRP. This material is released by nerves, and when released it causes inflammation in the nervous system.” states Ward.
Ward is strong in his belief that this will be the first that migraine patients will get drugs for prevention.