Obesity is linked to DNA

DNA rules! Whatever a character trait is found in your DNA, it will reflect on your personality. The trait may manifest itself in how you look, how you speak, how you work, or more. Your genes control your life and you may just have to live with it for better or for worse. But all is not lost. You still have your will power to make things better for yourself.

According to latest research study, one really bad character trait that you may inherit from your folks is obesity. If somewhere along your family tree there’s somebody there who’s obese, there’s a possibility that you may end up like one.

Latest study shows more proofs that obesity is inherited. That genes play an important role why some people are more prone to obesity than others.

The findings may help clarify why there are people who are more predisposed to gain weight and easily develop obesity-related conditions, researchers said.

Genetic specimens of over 300,000 people were examined by the investigators and found more than 140 sections across DNA samples they are studying that influences obesity.

The findings appear in two companion papers published Feb. 11 in the journal Nature.

“This is the first step toward identifying individual genes involved in body shape and size, the researchers said. “The proteins produced by the genes could offer targets for the development of new drugs to fight obesity.”

One of the reports concentrated on genes that determine where the fat is being deposited in the body and the role they play why we suffer certain illnesses. Our belly fat, for example, the more fat concentration we have there the higher the risk we have in acquiring systemic diseases such as type 2 diabetes and cardiovascular diseases compared to those with more fat concentration in the hips or those found in other parts of our body.

“We need to know these genetic locations because different fat deposits pose different health risks,” senior author Karen Mohlke, a professor of genetics at the University of North Carolina School of Medicine, said in a University of Michigan Health System news release.

“If we can figure out which genes influence where fat is deposited, it could help us understand the biology that leads to various health conditions, such as insulin resistance/diabetes, metabolic syndrome and heart disease,” she explained.

Another report examined the possible link that exists between genes and body mass index or BMI, used to estimate our body fat in relation to our height and weight. The report mentioned that the researchers discovered 97 genetic associations related to BMI. Another important discovery was the locations of the genes identified with BMI are connected to body parts that governs appetite and use of energy.

“Our work clearly shows that predisposition to obesity and increased BMI is not due to a single gene or genetic change,” Dr. Elizabeth Speliotes, senior author of the BMI paper, said in the news release. She is an assistant professor of internal medicine and of computational medicine and bioinformatics at the University of Michigan Health System.

“The large number of genes makes it less likely that one solution to beat obesity will work for everyone, and opens the door to possible ways we could use genetic clues to help defeat obesity,” she added.

Their next objective, the researchers revealed, is to determine exactly what these genes do and what role they play in making people prone to obesity.

 

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